Synthesis and identification of a novel tetrazole metabolite of the angiotensin II receptor antagonist DuP 753

Drug Metab Dispos. 1991 Nov-Dec;19(6):1160-2.

Authors

R A Stearns¹, G A Doss, R R Miller, S H Chiu

Affiliation

¹ Department of Animal and Exploratory Drug Metabolism, Merck Sharp and Dohme Research Laboratories, Rahway, NJ 07065-0900.

PMID: 1687025

No abstract available

Publication types

Comparative Study

MeSH terms

Angiotensin II / antagonists & inhibitors*
Angiotensin Receptor Antagonists*
Animals
Biotransformation
Biphenyl Compounds / metabolism*
Biphenyl Compounds / pharmacokinetics
Chromatography, High Pressure Liquid
Glucuronates / chemical synthesis
Glucuronates / metabolism
Glucuronates / pharmacokinetics
Haplorhini
Imidazoles / metabolism*
Imidazoles / pharmacokinetics
Liver / anatomy & histology
Liver / metabolism
Losartan
Magnetic Resonance Spectroscopy / methods
Spectrophotometry, Ultraviolet
Spectrum Analysis
Tetrazoles / chemical synthesis*
Tetrazoles / metabolism*
Tetrazoles / pharmacokinetics

Substances

Angiotensin Receptor Antagonists
Biphenyl Compounds
Glucuronates
Imidazoles
Tetrazoles
Angiotensin II
Losartan