Abstract
The plasmid-mediated class A carbapenemase KPC-2 was isolated from unrelated Klebsiella pneumoniae isolates in Medellin, Colombia. These KPC enzymes are the first from South America and the second isolation outside of the United States. The expanding geographic spread of KPC carbapenemases underscores the importance of clinical recognition of these enzymes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Bacterial Proteins / classification
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Bacterial Proteins / genetics*
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Bacterial Proteins / metabolism
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Base Sequence
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Carbapenems / pharmacology
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Drug Resistance, Bacterial / genetics
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Humans
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Isoelectric Point
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Klebsiella Infections / epidemiology
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Klebsiella pneumoniae / drug effects
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Klebsiella pneumoniae / enzymology
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Klebsiella pneumoniae / genetics*
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Klebsiella pneumoniae / isolation & purification*
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Molecular Sequence Data
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Open Reading Frames
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Plasmids / genetics*
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South America / epidemiology
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beta-Lactamases / classification
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beta-Lactamases / genetics*
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beta-Lactamases / metabolism
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Carbapenems
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beta-lactamase KPC-2
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beta-Lactamases
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carbapenemase