Abstract
Investigation of an acetone extract from Asafetida afforded two drimane sesquiterpene dienones (fetidones A and B, 1a,b) and several known sesquiterpene coumarin ethers, one of which (8-acetoxy-5-hydroxyumbelliprenin, 2a) showed potent and specific NF-kappaB-inhibiting properties. This, coupled to a negligible cytotoxicity, qualifies 2a as a new anti-inflammatory chemotype, and its occurrence in asafetida might rationalize the use of this gum resin to alleviate and prevent colon inflammatory disturbances.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Colon / drug effects
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Ferula / chemistry*
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India
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NF-kappa B / antagonists & inhibitors*
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Plants, Medicinal / chemistry*
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Polycyclic Sesquiterpenes
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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NF-kappa B
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Polycyclic Sesquiterpenes
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Sesquiterpenes
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drimane
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fetidone A
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fetidone B