A meroterpenoid NF-kappaB inhibitor and drimane sesquiterpenoids from Asafetida

J Nat Prod. 2006 Jul;69(7):1101-4. doi: 10.1021/np0600954.

Abstract

Investigation of an acetone extract from Asafetida afforded two drimane sesquiterpene dienones (fetidones A and B, 1a,b) and several known sesquiterpene coumarin ethers, one of which (8-acetoxy-5-hydroxyumbelliprenin, 2a) showed potent and specific NF-kappaB-inhibiting properties. This, coupled to a negligible cytotoxicity, qualifies 2a as a new anti-inflammatory chemotype, and its occurrence in asafetida might rationalize the use of this gum resin to alleviate and prevent colon inflammatory disturbances.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Colon / drug effects
  • Ferula / chemistry*
  • India
  • NF-kappa B / antagonists & inhibitors*
  • Plants, Medicinal / chemistry*
  • Polycyclic Sesquiterpenes
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • NF-kappa B
  • Polycyclic Sesquiterpenes
  • Sesquiterpenes
  • drimane
  • fetidone A
  • fetidone B