Abstract
Regulatory T cells suppress autoimmune responses to self-antigens. Recent studies, including one in this issue of Cell (Wu et al., 2006), suggest that the ability of T cells to choose between launching a productive immune response, functional inactivation, or developing into regulatory T cells depends upon the interplay of the key transcriptional regulators FOXP3 and NFAT.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
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Comment
MeSH terms
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Amino Acid Sequence
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Amino Acid Substitution
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Autoimmunity
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Base Sequence
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Biomarkers / metabolism
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CD24 Antigen / immunology
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Crystallography, X-Ray
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Forkhead Transcription Factors / chemistry
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Forkhead Transcription Factors / genetics
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Forkhead Transcription Factors / immunology*
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Gene Expression Regulation / genetics
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Gene Expression Regulation / immunology
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Genes, Reporter
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Humans
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Hydrogen Bonding
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Immune Tolerance*
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Interleukin-2 / genetics
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Interleukin-2 / immunology
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Jurkat Cells
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Luciferases / metabolism
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Lymphocyte Activation
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Models, Biological
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Molecular Sequence Data
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NFATC Transcription Factors / chemistry
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NFATC Transcription Factors / genetics
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NFATC Transcription Factors / immunology*
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Protein Structure, Tertiary
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Receptors, Interleukin-2 / immunology
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Sequence Homology, Amino Acid
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T-Lymphocytes, Regulatory / immunology
Substances
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Biomarkers
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CD24 Antigen
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FOXP3 protein, human
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Forkhead Transcription Factors
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Interleukin-2
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NFATC Transcription Factors
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Receptors, Interleukin-2
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Luciferases