A strategy for the design of selective RNA binding agents. Preparation and RRE RNA binding affinities of a neomycin-peptide nucleic acid heteroconjugate library

Soonsil Hyun; Kyung Hyun Lee; Jaehoon Yu

doi:10.1016/j.bmcl.2006.06.094

A strategy for the design of selective RNA binding agents. Preparation and RRE RNA binding affinities of a neomycin-peptide nucleic acid heteroconjugate library

Bioorg Med Chem Lett. 2006 Sep 15;16(18):4757-9. doi: 10.1016/j.bmcl.2006.06.094. Epub 2006 Jul 27.

Authors

Soonsil Hyun¹, Kyung Hyun Lee, Jaehoon Yu

Affiliation

¹ Department of Chemistry and Education, Seoul National University, Seoul 151-742, Republic of Korea.

PMID: 16875816
DOI: 10.1016/j.bmcl.2006.06.094

Abstract

We have successfully developed a new strategy for RNA ligand design, which applies the antisense concept to enhance and make more specific loop region interactions while at the same time preserving stem region anchoring. The heteroconjugates, prepared in this effort, have proven to be the most specific small molecule ligands against RRE RNA that have been uncovered to date.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Drug Design*
Gene Library*
Molecular Structure
Neomycin / chemistry*
Peptides / chemistry*
RNA / chemistry*
RNA / genetics*

Substances

Peptides
RNA
Neomycin