Immune reconstitution syndrome in a child with TB and HIV

Indian J Pediatr. 2006 Jul;73(7):627-9. doi: 10.1007/BF02759931.

Abstract

Immune reconstitution syndrome (IRS) is the transient worsening or appearance of new signs, symptoms or radiological manifestation of an opportunistic infection occurring after the initiation of Highly active antiretroviral therapy (HAART) and is not due to treatment failure or new infection. We describe a case of a HIV infected child with tubercular (mediastinal) lymphadenitis with worsening of clinical and radiological features on starting HAART.

Publication types

  • Case Reports

MeSH terms

  • Anti-HIV Agents / therapeutic use
  • Antiretroviral Therapy, Highly Active / adverse effects*
  • Antitubercular Agents / therapeutic use
  • CD4 Lymphocyte Count
  • Child
  • Glucocorticoids / therapeutic use
  • HIV Infections / complications
  • HIV Infections / drug therapy*
  • Humans
  • Immune System Diseases / diagnosis
  • Immune System Diseases / drug therapy
  • Immune System Diseases / immunology*
  • Male
  • Prednisolone / therapeutic use
  • Tuberculosis, Lymph Node / complications
  • Tuberculosis, Lymph Node / drug therapy

Substances

  • Anti-HIV Agents
  • Antitubercular Agents
  • Glucocorticoids
  • Prednisolone