Diagnosis of human rotavirus in stool specimens: comparison of different methods

Mymensingh Med J. 2006 Jul;15(2):183-7. doi: 10.3329/mmj.v15i2.41.

Abstract

A total of 345 stool specimens of hospitalized children below 5 years of age with acute gastroenteritis were tested for the presence of rotavirus by Polyacrylamide gel electrophoresis (PAGE), a monoclonal antibody based enzyme immunoassay (EIA) and a latex agglutination test (LAT). Detection rate for PAGE and EIA were 24.9% (345/86) and 20.9% (345/70) respectively. Using PAGE as the standard, the sensitivity and specificity of EIA were 75.6% and 98.1% respectively. The sensitivity of LAT was 70.9% with 100% specificity (LAT was done in only PAGE positive specimens). LAT appeared as the simplest and economic for both bed side and field use.

Publication types

  • Comparative Study

MeSH terms

  • Bangladesh / epidemiology
  • Child, Preschool
  • Electrophoresis, Polyacrylamide Gel
  • Feces / virology*
  • Female
  • Humans
  • Immunoenzyme Techniques
  • Infant
  • Infant, Newborn
  • Latex Fixation Tests
  • Male
  • Prevalence
  • Rotavirus / isolation & purification*
  • Rotavirus Infections / diagnosis*
  • Rotavirus Infections / epidemiology
  • Sensitivity and Specificity