Abstract
We investigated two polymorphisms of the epidermal growth factor receptor promoter as potential risk factors and prognostic markers for glioblastoma. The -216T allele (which results in a 30% higher activity) was more frequent in the patients compared with the control population (224/376 = 59.6% vs 165/352 = 46.8%; p = 0.0006) corresponding to an odd ratio of 1.67 (1.24; 2.25). A modest difference in median survival was also associated with the TT genotype.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Alleles
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Chi-Square Distribution
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ErbB Receptors / genetics*
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Female
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Follow-Up Studies
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Gene Frequency
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Glioblastoma / genetics*
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Humans
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Male
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Middle Aged
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Odds Ratio
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Polymorphism, Genetic*
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Promoter Regions, Genetic / genetics*
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Prospective Studies
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RNA, Messenger / metabolism
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Reverse Transcriptase Polymerase Chain Reaction / methods
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Risk Factors
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Sp1 Transcription Factor / metabolism*
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Survival Analysis
Substances
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RNA, Messenger
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Sp1 Transcription Factor
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ErbB Receptors