Abstract
Extrapulmonary undifferentiated small cell carcinomas, especially those arising in the upper aerodigestive tract, form a group of neoplasms with a clinical behavior which resembles small cell carcinoma of the lung. In 11 patients treated by combination chemotherapy an objective response rate of 82% was achieved for a median duration of 8+ months. Median survival for all patients was 12 months. Long-term survival was observed in those patients with limited disease who achieved a complete response after chemotherapy followed by radiotherapy.
MeSH terms
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Adult
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Aged
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Antineoplastic Combined Chemotherapy Protocols / adverse effects
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Bleomycin / administration & dosage
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Carcinoma, Small Cell / drug therapy*
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Carcinoma, Small Cell / mortality
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Cisplatin / administration & dosage
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Combined Modality Therapy
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Cyclophosphamide / administration & dosage
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Digestive System Neoplasms / drug therapy
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Doxorubicin / administration & dosage
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Etoposide / administration & dosage
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Female
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Genital Neoplasms, Female / drug therapy
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Humans
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Male
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Middle Aged
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Mitomycins / administration & dosage
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Neoplasm Staging
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Neoplasms, Unknown Primary / drug therapy
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Vincristine / administration & dosage
Substances
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Mitomycins
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Bleomycin
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Vincristine
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Etoposide
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Doxorubicin
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Cyclophosphamide
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Cisplatin