Abstract
Plasma total homocysteine (p-tHcy), serum folate (s-F), serum vitamin B-12 (s-B12) and plasma pyridoxal-5'-phosphate (p-PLP) were measured in epileptic children before and after a 20-week period of sodium valproate (group A, n=32) and carbamazepine (group B, n=20) monotherapy. P-tHcy significantly increased in both groups, s-F and s-B12 significantly increased in group A, while s-F and p-PLP significantly decreased in group B. Our study showed an early effect of antiepileptic drug treatment on homocysteine metabolism.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Anticonvulsants / pharmacology*
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Anticonvulsants / therapeutic use
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Carbamazepine / pharmacology*
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Carbamazepine / therapeutic use
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Child
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Child, Preschool
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Epilepsy / drug therapy*
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Epilepsy / metabolism
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Female
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Folic Acid / blood
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Homocysteine / metabolism*
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Humans
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Male
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Prospective Studies
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Pyridoxal Phosphate / blood
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Valproic Acid / pharmacology*
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Valproic Acid / therapeutic use
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Vitamin B 12 / blood
Substances
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Anticonvulsants
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Homocysteine
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Carbamazepine
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Pyridoxal Phosphate
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Valproic Acid
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Folic Acid
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Vitamin B 12