Abstract
A divergent approach to the 7-oxa (-)-muricatacin analogue 2, the corresponding (+)-enantiomer ent-2 and the furanolactone 3 is reported starting from D-xylose. The resulting lactones have shown a potent and selective in vitro cytotoxicity against certain human neoplastic cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Drug Screening Assays, Antitumor
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Furans / chemical synthesis*
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Furans / chemistry
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Furans / pharmacology*
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Humans
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In Vitro Techniques
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Lactones / chemical synthesis*
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Lactones / chemistry
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Lactones / pharmacology*
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Molecular Conformation
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Furans
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Lactones
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muricatacin
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7-goniofufurone