Abstract
This is a report of a phase I/II study of 13 patients treated with sodium pentosanpolysulfate (PPS) for chronic radiation-induced proctitis. A complete response was obtained in 82%, a partial response occurred in 9%, and 9% failed to respond to therapy. No significant toxicity was observed. It is concluded that PPS is an effective treatment for chronic radiation-induced proctitis and a phase III randomized, double-blind study of PPS versus placebo is planned.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Drug Evaluation
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Female
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Follow-Up Studies
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Humans
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Male
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Middle Aged
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Pentosan Sulfuric Polyester / administration & dosage
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Pentosan Sulfuric Polyester / therapeutic use*
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Polysaccharides / therapeutic use*
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Proctitis / drug therapy*
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Proctitis / etiology
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Radiation Injuries / drug therapy*
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Radiation Injuries / etiology
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Radiotherapy / adverse effects*
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Rectum / radiation effects
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Recurrence
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Remission Induction
Substances
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Polysaccharides
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Pentosan Sulfuric Polyester