Au(I)-catalyzed annulation of enantioenriched allenes in the enantioselective total synthesis of (-)-rhazinilam

J Am Chem Soc. 2006 Aug 16;128(32):10352-3. doi: 10.1021/ja0629110.

Abstract

Highly stereoselective Au(I)-catalyzed pyrrole additions to enantioenriched allenes afford a unique entry to optically active heterocycles. Asymmetric quaternary carbons can be installed with concurrent heterocycle annulation utilizing this methodology. The enantioenriched allenes are conveniently obtained by catalytic asymmetric acyl halide-aldehyde cyclocondensations and SN2' ring opening of the resulting enantioenriched beta-lactones. An enantioselective total synthesis of (-)-rhazinilam highlights the potential utility of this reaction technology in target-oriented synthesis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alkadienes / chemistry*
  • Alkaloids / chemical synthesis*
  • Alkaloids / chemistry
  • Catalysis
  • Gold / chemistry*
  • Indolizines / chemical synthesis
  • Indolizines / chemistry
  • Lactams / chemical synthesis
  • Lactams / chemistry
  • Molecular Structure
  • Stereoisomerism

Substances

  • Alkadienes
  • Alkaloids
  • Indolizines
  • Lactams
  • rhazinilam
  • propadiene
  • Gold