A novel approach incorporating sildenafil in the management of symptomatic neonates with Ebstein's anomaly

Pediatr Cardiol. 2006 Sep-Oct;27(5):614-7. doi: 10.1007/s00246-006-1203-9. Epub 2006 Aug 1.

Abstract

The neonatal presentation of Ebstein's anomaly is a distinct cyanotic lesion for which little can be done other than to maintain ductal patency or perform palliative surgery if improvement does not occur. We report two cases in which sildenafil was introduced to assist previously failed attempts at weaning of prostaglandin.

Publication types

  • Case Reports

MeSH terms

  • 3',5'-Cyclic-GMP Phosphodiesterases / antagonists & inhibitors
  • Dose-Response Relationship, Drug
  • Ebstein Anomaly / diagnostic imaging
  • Ebstein Anomaly / drug therapy*
  • Echocardiography
  • Female
  • Follow-Up Studies
  • Humans
  • Infant, Newborn
  • Male
  • Piperazines / administration & dosage
  • Piperazines / therapeutic use*
  • Purines
  • Radiography, Thoracic
  • Severity of Illness Index
  • Sildenafil Citrate
  • Sulfones
  • Vasodilator Agents / administration & dosage
  • Vasodilator Agents / therapeutic use*

Substances

  • Piperazines
  • Purines
  • Sulfones
  • Vasodilator Agents
  • Sildenafil Citrate
  • 3',5'-Cyclic-GMP Phosphodiesterases