Avinosol, a meroterpenoid-nucleoside conjugate with antiinvasion activity isolated from the marine sponge Dysidea sp

Ana R Diaz-Marrero; Pamela Austin; Rob Van Soest; Teatulohi Matainaho; Calvin D Roskelley; Michel Roberge; Raymond J Andersen

doi:10.1021/ol061333p

Avinosol, a meroterpenoid-nucleoside conjugate with antiinvasion activity isolated from the marine sponge Dysidea sp

Org Lett. 2006 Aug 17;8(17):3749-52. doi: 10.1021/ol061333p.

Authors

Ana R Diaz-Marrero¹, Pamela Austin, Rob Van Soest, Teatulohi Matainaho, Calvin D Roskelley, Michel Roberge, Raymond J Andersen

Affiliation

¹ Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z1.

PMID: 16898808
DOI: 10.1021/ol061333p

Abstract

[structure: see text] The new meroterpenoids avinosol (1), 3'-aminoavarone (2), and 3'-phenethylaminoavarone (3) have been isolated from the marine sponge Dysidea sp. collected in Papua New Guinea, and their structures were elucidated by analysis of spectroscopic data. Avinosol (1), which is apparently the first example of a naturally occurring meroterpenoid-nucleoside conjugate, showed antiinvasion activity in a cell-based assay.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents* / chemistry
Antineoplastic Agents* / isolation & purification
Antineoplastic Agents* / pharmacology
Drug Screening Assays, Antitumor
Dysidea / chemistry*
Female
Humans
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Papua New Guinea
Terpenes* / chemistry
Terpenes* / isolation & purification
Terpenes* / pharmacology
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Terpenes
avinosol