Diterpenes from "Pini Resina" and their preferential cytotoxic activity under nutrient-deprived condition

Planta Med. 2006 Oct;72(13):1231-4. doi: 10.1055/s-2006-947189. Epub 2006 Aug 10.

Abstract

In the course of our search for anticancer agents based on a novel anti-austerity strategy, we found that the 70 % EtOH extract of "Pini Resina" showed 100 % preferential cytotoxicity at the concentration of 50 microg/mL. Further bioassay-guided fractionation and purification led to the isolation of 15 compounds including one new compound 7-oxo-13 alpha-hydroxyabiet-8(14)-en-18-oic acid (1). Their structures were elucidated on the basis of spectroscopic analysis. Among the isolated compounds, methyl abieta-8,11,13-trien-18-oate (7) showed the most potent preferential cytotoxicity at 10 microg/mL under nutrient-deprived condition.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / toxicity*
  • Cell Line, Tumor
  • Chemical Fractionation
  • Culture Media
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification
  • Diterpenes / toxicity*
  • Humans
  • Pinus / chemistry*
  • Resins, Plant / chemistry
  • Resins, Plant / isolation & purification
  • Resins, Plant / toxicity*

Substances

  • Antineoplastic Agents, Phytogenic
  • Culture Media
  • Diterpenes
  • Resins, Plant
  • rosin