Abstract
Four alkaloids (1-4), three quinolone alkaloids (5-7), and three flavanoid glucosides (8-10) were isolated from the fruits of Evodia officinalis Dode, and their structures were determined from chemical and spectral data. Compounds, 3, 8, 9 and 10 were isolated from this plant for the first time. Of these compounds, 1-3 and 5-7 exhibited moderate cytotoxicities against cultured human colon carcinoma (HT-29), human breast carcinoma (MCF-7), and human hepatoblastoma (HepG-2). Compound 8 showed strong inhibitory effects on DNA topoisomerases I and II (70 and 96% inhibition at a concentration of 20 microM, respectively).
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification
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Alkaloids / pharmacology*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology*
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Cell Survival / drug effects
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DNA Topoisomerases, Type I / metabolism
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DNA Topoisomerases, Type II / metabolism
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology
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Evodia / chemistry*
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Fruit
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Glucosides / chemistry
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Glucosides / isolation & purification
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Glucosides / pharmacology*
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HT29 Cells
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Humans
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Inhibitory Concentration 50
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Molecular Structure
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Quinolones / chemistry
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Quinolones / isolation & purification
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Quinolones / pharmacology*
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Topoisomerase I Inhibitors
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Topoisomerase II Inhibitors
Substances
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Alkaloids
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Antineoplastic Agents
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Enzyme Inhibitors
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Glucosides
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Quinolones
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Topoisomerase I Inhibitors
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Topoisomerase II Inhibitors
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DNA Topoisomerases, Type I
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DNA Topoisomerases, Type II