Abstract
In this randomized pilot clinical trial, the authors tested the hypothesis that using gabapentin as an add-on agent in the treatment of postoperative pain reduces the occurrence of postoperative delirium. Postoperative delirium occurred in 5/12 patients (42%) who received placebo vs 0/9 patients who received gabapentin, p = 0.045. The reduction in delirium appears to be secondary to the opioid-sparing effect of gabapentin.
Publication types
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Randomized Controlled Trial
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Research Support, N.I.H., Extramural
MeSH terms
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Amines / therapeutic use*
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Analgesics / therapeutic use
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Cyclohexanecarboxylic Acids / therapeutic use*
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Delirium / etiology*
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Delirium / prevention & control*
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Feasibility Studies
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Female
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Gabapentin
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Humans
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Male
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Middle Aged
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Neurosurgical Procedures / adverse effects*
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Pain Measurement / drug effects
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Pain, Postoperative / etiology*
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Pain, Postoperative / prevention & control*
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Pilot Projects
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Placebo Effect
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Premedication / methods*
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Spine / surgery
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Treatment Outcome
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gamma-Aminobutyric Acid / therapeutic use*
Substances
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Amines
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Analgesics
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Cyclohexanecarboxylic Acids
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gamma-Aminobutyric Acid
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Gabapentin