Abstract
After examining a variety of detergents we find that receptors for human alpha interferon can be solubilized, in active form, from plasma membranes of lymphoid cells using the detergent CHAPS. The complexes formed, in solution, with interferon are stable enough to be separated chromatographically.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cholic Acids / pharmacology*
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Detergents / pharmacology*
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Humans
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Interferons / metabolism*
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Lymphocytes / analysis
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Molecular Weight
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Receptors, Immunologic / isolation & purification*
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Receptors, Immunologic / metabolism
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Receptors, Interferon
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Surface-Active Agents / pharmacology*
Substances
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Cholic Acids
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Detergents
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Receptors, Immunologic
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Receptors, Interferon
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Surface-Active Agents
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Interferons
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3-((3-cholamidopropyl)dimethylammonium)-1-propanesulfonate