RETRACTED: Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo

Mol Cell. 2006 Aug;23(4):471-82. doi: 10.1016/j.molcel.2006.06.029.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the editors. Molecular Cell has retracted this article following the results of an investigation carried out by Leiden University Medical Center's Committee of Scientific Integrity, which concluded that unacceptable data manipulation by the first author Maria Fousteri led to breaches of scientific integrity, making these results unreliable. These manipulations include duplications (Figures 1C, 2A, 3D [CSB panel], and 5C [p300 panel]), image tilt correction (Figure 4D [CSB panel]), and aesthetic corrections. Additional details can be found in the redacted version of the investigation report (https://www.lumc.nl/cen/att/80813053317221/1263833/report-lumc-committee-scientific-integrity).

Publication types

  • Research Support, Non-U.S. Gov't
  • Retracted Publication

MeSH terms

  • Cells, Cultured
  • Chromatin Assembly and Disassembly*
  • Chromosomal Proteins, Non-Histone / metabolism*
  • Cross-Linking Reagents
  • DNA / radiation effects
  • DNA Damage
  • DNA Helicases / metabolism*
  • DNA Repair Enzymes / metabolism*
  • DNA Repair*
  • DNA-Binding Proteins / metabolism
  • Fibroblasts / radiation effects
  • Humans
  • Models, Genetic
  • Poly-ADP-Ribose Binding Proteins
  • RNA Polymerase II / metabolism*
  • RNA Splicing Factors
  • Transcription Factors / metabolism*
  • Transcription, Genetic / radiation effects
  • Transcriptional Elongation Factors / metabolism
  • Ubiquitin-Protein Ligases / metabolism
  • Ultraviolet Rays

Substances

  • Chromosomal Proteins, Non-Histone
  • Cross-Linking Reagents
  • DDB1 protein, human
  • DNA-Binding Proteins
  • ERCC8 protein, human
  • Poly-ADP-Ribose Binding Proteins
  • RNA Splicing Factors
  • Transcription Factors
  • Transcriptional Elongation Factors
  • XAB2 protein, human
  • transcription factor S-II
  • DNA
  • Ubiquitin-Protein Ligases
  • RNA Polymerase II
  • DNA Helicases
  • ERCC6 protein, human
  • DNA Repair Enzymes