Abstract
The NALP3-inflammasome is a protein complex that stimulates caspase-1 activation to promote the processing and secretion of proinflammatory cytokines. Recent work indicates that the NALP3-inflammasome can be activated by endogenous "danger signals" as well as compounds associated with pathogens (Kanneganti et al., 2006; Mariathasan et al., 2006, Martinon et al., 2006; Sutterwala et al., 2006). Here, we discuss new insights into the regulation of caspase-1 activity in the inflammatory response.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Adenosine Triphosphate / metabolism
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Animals
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Apoptosis Regulatory Proteins / genetics
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Apoptosis Regulatory Proteins / metabolism
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CARD Signaling Adaptor Proteins
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Calcium Pyrophosphate / metabolism
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Calcium-Binding Proteins / genetics
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Calcium-Binding Proteins / metabolism
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Carrier Proteins / genetics
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Carrier Proteins / metabolism*
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Caspase 1 / metabolism*
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Cytoskeletal Proteins / genetics
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Cytoskeletal Proteins / metabolism
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Enzyme Activation
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Humans
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Immune System / physiology*
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Inflammation / metabolism*
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Interleukins / immunology
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NLR Family, Pyrin Domain-Containing 3 Protein
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Oxidative Stress*
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Salmonella Infections / immunology
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Salmonella typhimurium / immunology
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Uric Acid / metabolism
Substances
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Apoptosis Regulatory Proteins
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CARD Signaling Adaptor Proteins
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Calcium-Binding Proteins
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Carrier Proteins
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Cytoskeletal Proteins
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Interleukins
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Ipaf protein, mouse
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NLR Family, Pyrin Domain-Containing 3 Protein
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NLRP3 protein, human
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Pycard protein, mouse
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Uric Acid
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Adenosine Triphosphate
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Caspase 1
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Calcium Pyrophosphate