Intermolecular [4 + 2] cycloaddition of o-quinodimethanes derived from ene-bis(sulfinylallenes)

J Org Chem. 2006 Sep 1;71(18):6908-14. doi: 10.1021/jo061014b.

Abstract

Intermolecular [4 + 2] cycloaddition of o-quinodimethanes, prepared in situ from ene-bis(propargyl alcohols) and benzenesulfenyl chloride via ene-bis(sulfinylallene) formation, was investigated. Benzene-bridged bis(propargyl alcohols) reacted with both electron-deficient and electron-rich olefins to give the corresponding [4 + 2] cycloadducts. Ethylene-bridged bis(propargyl alcohols) underwent similar cycloaddition with electron-deficient olefins. Construction of some heterocycles based on the newly developed sequential reaction is also described.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chemistry, Organic / methods*
  • Methane / chemistry*
  • Polycyclic Aromatic Hydrocarbons / chemical synthesis*
  • Quinones / chemistry*
  • Sulfur Compounds / chemistry*

Substances

  • Polycyclic Aromatic Hydrocarbons
  • Quinones
  • Sulfur Compounds
  • Methane