Abstract
Two new taraxasterane-type triterpenes, 20beta,28-epoxy-28alpha-methoxytaraxasteran-3beta-ol (1) and 20beta,28-epoxytaraxaster-21-en-3beta-ol (2), were isolated from an ethyl acetate extract of the leaves of Nerium oleander, together with ursane-type triterpenes, 28-nor-urs-12-ene-3beta,17beta-diol (3) and 3beta-hydroxyurs-12-en-28-aldehyde (4). The structures of 1 and 2 were established on the basis of their spectroscopic data. Anti-inflammatory activity of 1-4 was examined on the basis of inhibitory activity against the induction of intercellular adhesion molecule-1 (ICAM-1). Cytotoxic activity of 1-4 was evaluated against four human cell lines, A-549, WI-38, VA-13, and HepG2 cells.
MeSH terms
-
Anti-Inflammatory Agents, Non-Steroidal* / chemistry
-
Anti-Inflammatory Agents, Non-Steroidal* / classification
-
Anti-Inflammatory Agents, Non-Steroidal* / isolation & purification
-
Anti-Inflammatory Agents, Non-Steroidal* / pharmacology
-
Antineoplastic Agents, Phytogenic* / chemistry
-
Antineoplastic Agents, Phytogenic* / classification
-
Antineoplastic Agents, Phytogenic* / isolation & purification
-
Antineoplastic Agents, Phytogenic* / pharmacology
-
Drug Screening Assays, Antitumor
-
Humans
-
Intercellular Adhesion Molecule-1 / drug effects
-
Japan
-
Molecular Structure
-
Nerium / chemistry*
-
Nuclear Magnetic Resonance, Biomolecular
-
Plant Leaves / chemistry
-
Plants, Medicinal / chemistry*
-
Triterpenes* / chemistry
-
Triterpenes* / classification
-
Triterpenes* / isolation & purification
-
Triterpenes* / pharmacology
-
Tumor Cells, Cultured
Substances
-
20beta,28-epoxy-28alpha-methoxytaraxasteran-3beta-ol
-
20beta,28-epoxytaraxaster-21-en-3beta-ol
-
Anti-Inflammatory Agents, Non-Steroidal
-
Antineoplastic Agents, Phytogenic
-
Triterpenes
-
Intercellular Adhesion Molecule-1