Abstract
Three new photoactivated insecticidal thiophene derivatives, xanthopappins A-C (1-3), were isolated from Xanthopappus subacaulis, along with three known thiophene acetylenes, 5-hydroxymethyl-2-(E)-hept-5-ene-1,3-diynylthiophene (4), 5-(1,2-dihydroxyethyl)-2-(E)-hept-5-ene-1,3-diynylthiophene (5), and 5-(1,2-diacetoxyethyl)-2-(E)-hept-5-ene-1,3-diynylthiophene (6). The structures of 1-3 were elucidated by spectroscopic methods. Compounds 1-6 exhibited significant photoactivated insecticidal activity against the fourth-instar larvae of the Asian tiger mosquito.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aedes / drug effects*
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Animals
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Asteraceae / chemistry*
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Insecticides / chemistry
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Insecticides / isolation & purification*
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Insecticides / pharmacology
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Larva / drug effects
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Molecular Structure
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Photochemistry / methods
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Plants, Medicinal / chemistry*
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Thiophenes / chemistry
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Thiophenes / isolation & purification*
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Thiophenes / pharmacology
Substances
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Drugs, Chinese Herbal
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Insecticides
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Thiophenes
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xanthopappin A
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xanthopappin B
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xanthopappin C