T-bet/GATA-3 ratio is a surrogate measure of Th1/Th2 cytokine profiles and may be novel targets for CpG ODN treatment in asthma patients

Chin Med J (Engl). 2006 Aug 20;119(16):1396-9.
No abstract available

Publication types

  • Comparative Study

MeSH terms

  • Adjuvants, Immunologic / pharmacology
  • Asthma / blood*
  • Cells, Cultured
  • Cytokines / metabolism*
  • Enzyme-Linked Immunosorbent Assay / methods
  • Female
  • GATA3 Transcription Factor / genetics
  • GATA3 Transcription Factor / metabolism*
  • Humans
  • Interferon-gamma / metabolism
  • Interleukin-13 / metabolism
  • Interleukin-4 / metabolism
  • Interleukin-5 / metabolism
  • Leukocytes, Mononuclear / cytology
  • Leukocytes, Mononuclear / drug effects
  • Leukocytes, Mononuclear / metabolism
  • Male
  • Oligodeoxyribonucleotides / pharmacology*
  • Pulmonary Disease, Chronic Obstructive / blood
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Reverse Transcriptase Polymerase Chain Reaction / methods
  • Statistics as Topic
  • T-Box Domain Proteins
  • T-Lymphocytes, Helper-Inducer / cytology
  • T-Lymphocytes, Helper-Inducer / drug effects*
  • T-Lymphocytes, Helper-Inducer / metabolism
  • Th1 Cells / cytology
  • Th1 Cells / drug effects
  • Th1 Cells / metabolism
  • Th2 Cells / cytology
  • Th2 Cells / drug effects
  • Th2 Cells / metabolism
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*

Substances

  • Adjuvants, Immunologic
  • CPG-oligonucleotide
  • Cytokines
  • GATA3 Transcription Factor
  • Interleukin-13
  • Interleukin-5
  • Oligodeoxyribonucleotides
  • RNA, Messenger
  • T-Box Domain Proteins
  • T-box transcription factor TBX21
  • Transcription Factors
  • Interleukin-4
  • Interferon-gamma