N,N'-Diarylcyanoguanidines as antagonists of the CXCR2 and CXCR1 chemokine receptors

Hong Nie; Katherine L Widdowson; Michael R Palovich; Wei Fu; John D Elliott; Deborah L Bryan; Miriam Burman; Dulcie B Schmidt; James J Foley; Henry M Sarau; Jakob Busch-Petersen

doi:10.1016/j.bmcl.2006.08.042

N,N'-Diarylcyanoguanidines as antagonists of the CXCR2 and CXCR1 chemokine receptors

Bioorg Med Chem Lett. 2006 Nov 1;16(21):5513-6. doi: 10.1016/j.bmcl.2006.08.042. Epub 2006 Aug 24.

Authors

Hong Nie¹, Katherine L Widdowson, Michael R Palovich, Wei Fu, John D Elliott, Deborah L Bryan, Miriam Burman, Dulcie B Schmidt, James J Foley, Henry M Sarau, Jakob Busch-Petersen

Affiliation

¹ GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, USA.

PMID: 16934456
DOI: 10.1016/j.bmcl.2006.08.042

Abstract

A series of N-(2-hydroxy-3-sulfonamidobenzene)-N'-arylcyanoguanidines was prepared. In general, these compounds proved to be potent antagonists of CXCR2 while the selectivity versus CXCR1 ranged from non-selective to >200-fold.

MeSH terms

Guanidines / chemistry
Guanidines / pharmacology*
Humans
Receptors, Interleukin-8A / antagonists & inhibitors*
Receptors, Interleukin-8B / antagonists & inhibitors*

Substances

Guanidines
Receptors, Interleukin-8A
Receptors, Interleukin-8B
dicyandiamido