Cryptic and complex chromosomal rearrangements and the deletion of TP53 gene in a patient with leukemic mantle cell lymphoma

Lijun Zhang; Williams F Kern; Zongxing Yu; John J Mulvihill; Shibo Li

doi:10.1016/j.cancergencyto.2006.04.002

Cryptic and complex chromosomal rearrangements and the deletion of TP53 gene in a patient with leukemic mantle cell lymphoma

Cancer Genet Cytogenet. 2006 Sep;169(2):169-73. doi: 10.1016/j.cancergencyto.2006.04.002.

Authors

Lijun Zhang¹, Williams F Kern, Zongxing Yu, John J Mulvihill, Shibo Li

Affiliation

¹ Department of Pediatrics, The University of Oklahoma Health Sciences Center, 941 Stanton L. Young Blvd., BSEB 224, Oklahoma City, OK 73104, USA.

PMID: 16938577
DOI: 10.1016/j.cancergencyto.2006.04.002

Abstract

We present a case of leukemic mantle cell lymphoma with cryptic and complex chromosomal rearrangements, including multiple-way translocations involving chromosomes 8q24, 14q11/q32, 17p13.3, 17p13.1, 21q22, and 21q22; a deletion of the long arm of chromosome 10 [del(10)(q24)]; and a deletion of the TP53 gene in addition to t(11;14). We speculate that this series of chromosomal changes may disrupt the IgH gene, activate the c-MYC oncogene, inactivate the p53 tumor suppressor gene, and disrupt other cancer-related genes either within or flanking the chromosomal breakpoints. This combinational effect causes the progression of mantle cell lymphoma.

Publication types

Case Reports

MeSH terms

Bone Marrow / pathology
Genes, p53*
Humans
In Situ Hybridization, Fluorescence
Lymphoma, Mantle-Cell / genetics*
Male
Middle Aged
Translocation, Genetic*