Two new 15-deoxycimigenol-type and three new 24-epi-cimigenol-type glycosides from Cimicifuga Rhizome

Hitoshi Yoshimitsu; Makiko Nishida; Masahide Sakaguchi; Toshihiro Nohara

doi:10.1248/cpb.54.1322

Two new 15-deoxycimigenol-type and three new 24-epi-cimigenol-type glycosides from Cimicifuga Rhizome

Chem Pharm Bull (Tokyo). 2006 Sep;54(9):1322-5. doi: 10.1248/cpb.54.1322.

Authors

Hitoshi Yoshimitsu¹, Makiko Nishida, Masahide Sakaguchi, Toshihiro Nohara

Affiliation

¹ Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Kumamoto 862-0082, Japan. [email protected]

PMID: 16946545
DOI: 10.1248/cpb.54.1322

Abstract

Two new 15-deoxycimigenol-type (1, 2) and three new 24-epi-cimigenol-type glycosides (3-5) were isolated from Cimicifuga Rhizome, and the structures were elucidated on the basis of spectroscopic data including 2D NMR spectra and chemical evidence. The two new 15-deoxycimigenol-type glycosides were the first cimigenol-type glycosides lacking a hydroxyl group at C-15.

MeSH terms

Cimicifuga / chemistry*
Glycosides / chemistry*
Glycosides / isolation & purification
Magnetic Resonance Spectroscopy / methods
Magnetic Resonance Spectroscopy / standards
Molecular Conformation
Reference Standards
Sensitivity and Specificity
Stereoisomerism

Substances

15-deoxycimigenol
24-epi-cimigenol
Glycosides