Transforming growth factor-beta and epidermal growth factor modulate basal and interleukin-6-induced amino acid uptake and acute phase protein synthesis in cultured rat hepatocytes

J Bereta; K Szuba; W Fiers; J Gauldie; A Koj

doi:10.1016/0014-5793(90)81503-g

Transforming growth factor-beta and epidermal growth factor modulate basal and interleukin-6-induced amino acid uptake and acute phase protein synthesis in cultured rat hepatocytes

FEBS Lett. 1990 Jun 18;266(1-2):48-50. doi: 10.1016/0014-5793(90)81503-g.

Authors

J Bereta¹, K Szuba, W Fiers, J Gauldie, A Koj

Affiliation

¹ Institute of Molecular Biology, Jagiellonian University, Krakow, Poland.

PMID: 1694787
DOI: 10.1016/0014-5793(90)81503-g

Abstract

Rat hepatocytes cultured for 2 days with interleukin-6 show increased synthesis of acute phase proteins and enhanced accumulation of 14C-labelled alpha-aminoisobutyric acid. Transforming growth factor-beta 1 (0.1-10 ng/ml) inhibits whereas epidermal growth factor (1-100 ng/ml) enhances both basal and interleukin-6-induced amino acid uptake by rat hepatocytes with only a slight alteration of acute phase protein synthesis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acute-Phase Proteins / biosynthesis*
Amino Acids / metabolism*
Animals
Biological Transport / drug effects
Cells, Cultured
DNA / biosynthesis
Epidermal Growth Factor / pharmacology*
In Vitro Techniques
Interleukin-6 / pharmacology*
Liver / metabolism*
Rats
Time Factors
Transforming Growth Factors / pharmacology*

Substances

Acute-Phase Proteins
Amino Acids
Interleukin-6
Epidermal Growth Factor
Transforming Growth Factors
DNA