Abstract
A novel series of hydantoin derivatives were identified by in vivo studies as tissue selective androgen receptor modulators. SAR around this series revealed that the function of the ligand could be altered by minor structural modification.
MeSH terms
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Androgen Antagonists / pharmacology*
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Animals
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Binding Sites
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Hydantoins / chemical synthesis*
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Hydantoins / pharmacology*
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Male
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Prostate / drug effects*
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Prostate / metabolism
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Rats
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Receptors, Androgen / metabolism*
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Structure-Activity Relationship
Substances
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Androgen Antagonists
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Hydantoins
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Receptors, Androgen