Abstract
Syntheses of new glycosylated neutral and cationic porphyrin dimers linked at the meso-position via a flexible hydrocarbon chain are described. A detailed 1H and 13C NMR study allows their complete structural elucidation. The UV-visible, fluorescence and MALDI mass spectra are also presented. Photocytotoxicities of these compounds against K562 leukaemia cell line are compared to those of Photofrin II.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Survival / drug effects
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Dihematoporphyrin Ether
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Dimerization
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Glycosylation
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Humans
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K562 Cells
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Photochemotherapy / methods*
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Porphyrins / chemical synthesis*
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Porphyrins / pharmacology*
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Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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Spectrum Analysis
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Structure-Activity Relationship
Substances
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Porphyrins
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Dihematoporphyrin Ether