Abstract
A 3-year retrospective study evaluated the effectiveness and safety of cefepime plus a fluoroquinolone for treating bone and joint infections caused by Gram-negative bacilli (GNB) in 28 patients. Intra-operative cultures yielded primarily Pseudomonas spp. and Enterobacter cloacae. Full recovery (cure) was observed in 79% of patients. There were no serious adverse effects and no resistant organisms were isolated. The results of the study confirmed the safety and effectiveness of cefepime combined with a fluoroquinolone for the treatment of bone and joint infections caused by Gram-negative bacilli.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / therapeutic use
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Bone Diseases, Infectious / drug therapy*
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Cefepime
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Cephalosporins / administration & dosage*
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Cephalosporins / therapeutic use
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Ciprofloxacin / administration & dosage*
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Ciprofloxacin / therapeutic use
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Drug Therapy, Combination
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Female
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Gram-Negative Bacterial Infections / drug therapy*
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Humans
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Joint Diseases / drug therapy*
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Male
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Middle Aged
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Ofloxacin / administration & dosage*
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Ofloxacin / therapeutic use
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Retrospective Studies
Substances
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Anti-Bacterial Agents
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Cephalosporins
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Ciprofloxacin
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Cefepime
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Ofloxacin