FLT3/D835 mutation and inversion of chromosome 16 in leukemic transformation of myelofibrosis

Milica Colovic; Vladimir Jurisic; Sonja Pavlovic; Tatjana Terzic; Natasa Colovic

doi:10.1016/j.ejim.2006.02.028

FLT3/D835 mutation and inversion of chromosome 16 in leukemic transformation of myelofibrosis

Eur J Intern Med. 2006 Oct;17(6):434-5. doi: 10.1016/j.ejim.2006.02.028.

Authors

Milica Colovic¹, Vladimir Jurisic, Sonja Pavlovic, Tatjana Terzic, Natasa Colovic

Affiliation

¹ Institute of Hematology, University Clinical Center, Belgrade, Serbia.

PMID: 16962953
DOI: 10.1016/j.ejim.2006.02.028

Abstract

We present an atypical case of myelofibrosis developing into secondary leukemia FAB subtype M4, with inversion of chromosome 16, FLT3/D835 point mutation and diffuse osteolytic lesions accompanied by elevated TNF-alpha. The simultaneous occurrence of these mutations reflects the progressive association of genetic lesions developing into secondary leukemia with a relatively benign course.