Abstract
Widespread circulation of human enterovirus 71 was discovered in a prospective study of fecal samples obtained from healthy Norwegian children. Molecular characterization of the virus determined that it belonged to genotype C1. Complete sequencing of this strain, HEV71 804/NO/03, revealed differences in the 5'UTR and polymerase with respect to more pathogenic genotypes that may explain its reduced neurovirulence.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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5' Untranslated Regions / genetics
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Amino Acid Sequence
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Carrier State / epidemiology*
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Cohort Studies
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DNA-Directed RNA Polymerases / genetics
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Enterovirus / classification
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Enterovirus / genetics*
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Enterovirus Infections / epidemiology*
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Feces / virology
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Female
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Humans
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Infant
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Male
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Molecular Epidemiology
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Molecular Sequence Data
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Norway / epidemiology
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Phylogeny
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Prospective Studies
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Sequence Alignment
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Species Specificity
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Viral Proteins / genetics
Substances
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5' Untranslated Regions
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Viral Proteins
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DNA-Directed RNA Polymerases
Associated data
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GENBANK/DQ317216
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GENBANK/DQ317217
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GENBANK/DQ317218
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GENBANK/DQ317219
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GENBANK/DQ317220
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GENBANK/DQ317221
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GENBANK/DQ317222
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GENBANK/DQ317223
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GENBANK/DQ317224
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GENBANK/DQ317225
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GENBANK/DQ317226
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GENBANK/DQ317227