Abstract
The authors have previously shown an effect of dopamine transporter genotype on acute subjective responses to d-amphetamine, which may affect risk of addiction. They now report the results of an evaluation of the role of the serotonin transporter gene (HTT) using a double-blind, placebo-controlled, crossover design in which subjects (N = 101) completed self-report measures of subjective effect. The separate and combined analyses of the gene-linked polymorphic region (5-HTTLPR) and the Intron 2 VNTR suggest that these two HTT polymorphisms may contribute to acute subjective responses to d-amphetamine with a small effect.
Publication types
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Randomized Controlled Trial
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Research Support, N.I.H., Extramural
MeSH terms
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Adolescent
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Adult
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Affect / drug effects*
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Alleles
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Amphetamine-Related Disorders / genetics*
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Amphetamine-Related Disorders / psychology
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Arousal / drug effects
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Arousal / genetics
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Cross-Over Studies
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Dextroamphetamine / pharmacology*
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Dose-Response Relationship, Drug
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Double-Blind Method
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Female
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Gene Frequency / genetics
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Genotype*
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Humans
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Introns / genetics*
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Male
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Minisatellite Repeats / genetics*
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Polymerase Chain Reaction
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Polymorphism, Genetic / genetics*
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Serotonin Plasma Membrane Transport Proteins / genetics*
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Substance-Related Disorders / genetics
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Substance-Related Disorders / psychology
Substances
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Serotonin Plasma Membrane Transport Proteins
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Dextroamphetamine