Abstract
The synthesis of new 1beta-methylcarbapenems 1a-d bearing aminopyrimidinylthioether moiety at C-5 position of pyrrolidine ring and their antibacterial activities are described. All the compounds exhibited potent antibacterial activity. Of these carbapenems, 1d showed the best combination of antibacterial activity and stability to dehydropeptidase-I (DHP-I).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / metabolism
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Anti-Bacterial Agents / pharmacology
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Carbapenems / chemical synthesis*
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Carbapenems / chemistry
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Carbapenems / metabolism
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Carbapenems / pharmacology
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Dipeptidases / metabolism
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Molecular Structure
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Pyrimidines / chemical synthesis*
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Pyrimidines / chemistry
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Pyrimidines / metabolism
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Pyrimidines / pharmacology
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Sulfides / chemical synthesis*
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Sulfides / chemistry
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Sulfides / metabolism
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Sulfides / pharmacology
Substances
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Anti-Bacterial Agents
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Carbapenems
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Pyrimidines
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Sulfides
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Dipeptidases
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dipeptidase