Urinary bactericidal activity of extended-release ciprofloxacin (1,000 milligrams) versus levofloxacin (500 milligrams) in healthy volunteers receiving a single oral dose

Florian M E Wagenlehner; Martina Kinzig-Schippers; Uwe Tischmeyer; Christine Wagenlehner; Fritz Sörgel; Kurt G Naber

doi:10.1128/AAC.00477-06

Urinary bactericidal activity of extended-release ciprofloxacin (1,000 milligrams) versus levofloxacin (500 milligrams) in healthy volunteers receiving a single oral dose

Antimicrob Agents Chemother. 2006 Nov;50(11):3947-9. doi: 10.1128/AAC.00477-06. Epub 2006 Sep 18.

Authors

Florian M E Wagenlehner¹, Martina Kinzig-Schippers, Uwe Tischmeyer, Christine Wagenlehner, Fritz Sörgel, Kurt G Naber

Affiliation

¹ Department of Urology, Hospital St. Elisabeth, St. Elisabeth Str. 23, D-94315 Straubing, Germany. [email protected]

Abstract

Twelve volunteers received a single oral dose of 1,000 mg extended-release (XR) ciprofloxacin versus 500 mg levofloxacin to assess urinary bactericidal titers (UBTs) against common uropathogens. Areas under UBT-time curves were significantly larger for Proteus mirabilis with XR ciprofloxacin and for staphylococci with levofloxacin.

Publication types

Comparative Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / administration & dosage
Anti-Bacterial Agents / pharmacology*
Area Under Curve
Ciprofloxacin / administration & dosage
Ciprofloxacin / pharmacology*
Cross-Over Studies
Delayed-Action Preparations
Humans
Levofloxacin*
Ofloxacin / pharmacology*
Proteus mirabilis / drug effects*
Staphylococcus / drug effects
Urine / microbiology*

Substances

Anti-Bacterial Agents
Delayed-Action Preparations
Ciprofloxacin
Levofloxacin
Ofloxacin