Abstract
Chromobacterium violaceum produces autoinducers, including homoserine lactones (HSLs), for genetic regulation. Among the seven HSLs derived from C. violaceum we evaluated, only C(12)-HSL stimulated the production of inflammatory cytokines in mammalian monocytic cell lines through the activation of the NF-kappaB signaling pathway besides their quorum-sensing role, like 3-oxo-C(12)-HSL from Pseudomonas aeruginosa.
MeSH terms
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4-Butyrolactone / analogs & derivatives*
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4-Butyrolactone / metabolism
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4-Butyrolactone / pharmacology
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Animals
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Cells, Cultured
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Chromobacterium / metabolism*
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Cytokines / metabolism*
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Homoserine / analogs & derivatives*
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Homoserine / metabolism
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Homoserine / pharmacology
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Humans
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Macrophage Activation
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Macrophages / drug effects*
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Macrophages / immunology
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Mice
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Monocytes / drug effects*
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Monocytes / immunology
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NF-kappa B / agonists
Substances
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Cytokines
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N-dodecanoyl-DL-homoserine lactone
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NF-kappa B
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Homoserine
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4-Butyrolactone