Disturbed assembly of human cerebral microtubules in Alzheimer's disease

P N Shevtsov; E F Shevtsova; G Sh Burbaeva; S O Bachurin

doi:10.1007/s10517-006-0145-9

Disturbed assembly of human cerebral microtubules in Alzheimer's disease

Bull Exp Biol Med. 2006 Feb;141(2):265-8. doi: 10.1007/s10517-006-0145-9.

Authors

P N Shevtsov¹, E F Shevtsova, G Sh Burbaeva, S O Bachurin

Affiliation

¹ Laboratory of Neurochemistry, National Center for Mental Health, Russian Academy of Medical Sciences. [email protected]

PMID: 16984114
DOI: 10.1007/s10517-006-0145-9

Abstract

It is shown for the first time that microtubular proteins isolated from the brain of patients with Alzheimer's disease can in vitro polymerize into microtubules with abnormal structure.

MeSH terms

Aged
Aged, 80 and over
Alzheimer Disease / metabolism*
Alzheimer Disease / pathology*
Brain / metabolism*
Brain / ultrastructure*
Humans
In Vitro Techniques
Male
Microscopy, Electron
Microtubule-Associated Proteins / metabolism
Microtubules / metabolism*
Microtubules / ultrastructure*
Tubulin / metabolism

Substances

Microtubule-Associated Proteins
Tubulin