Loss of anti-tumour immunogenicity of a somatic cell hybrid line with increasing subculture

Br J Cancer. 1975 Jul;32(1):139-41. doi: 10.1038/bjc.1975.140.

Abstract

Good immunoprotection was afforded by A9/SEWA somatic hybrid cells in the C3H mouse/C3H Py tumour system, confirming results previously obtained in the A.SW mouse/SEWA tumour system. However, in this study the immunogenicity decreased with increasing serial subculture of the hybrid line and concomitant chromosome loss.

MeSH terms

  • Animals
  • Cell Line
  • Chromosomes
  • Hybrid Cells / immunology*
  • Immunization
  • In Vitro Techniques
  • Karyotyping
  • Mice
  • Mice, Inbred C3H
  • Neoplasms, Experimental / immunology*
  • Polyomavirus