DNA vaccine design

Methods Mol Med. 2006:127:3-10. doi: 10.1385/1-59745-168-1:3.

Abstract

The purpose of this chapter is to present basic strategies for the construction of DNA vaccines. This chapter discusses considerations relevant to the selection of a target gene, construction of a DNA expression vector for use as a vaccine, and molecular modifications of the vector to improve protein expression and to augment immunogenicity.

Publication types

  • Review

MeSH terms

  • Animals
  • Gene Expression*
  • Genetic Engineering / methods
  • Genetic Vectors*
  • Humans
  • Plasmids / genetics
  • Plasmids / immunology
  • Vaccines, DNA / genetics*
  • Vaccines, DNA / immunology

Substances

  • Vaccines, DNA