Acute transient encephalopathy following paclitaxel treatment in an adolescent with a recurrent suprasellar germinoma

Pediatr Blood Cancer. 2008 Mar;50(3):699-700. doi: 10.1002/pbc.21040.

Abstract

Paclitaxel is an antineoplastic agent that is used in the treatment of a variety of solid tumors. Dose-limiting side effects of myelosuppression and peripheral neuropathy are well known. Paclitaxel has minimal penetration of the blood-brain barrier and central nervous system side effects are rare. However, transient encephalopathy following paclitaxel infusion has been described in adults but not in children. We present the case of a 14-year-old female with a recurrent suprasellar germinoma who developed an acute encephalopathy 4-6 hr following paclitaxel infusion.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antineoplastic Agents, Phytogenic / administration & dosage
  • Antineoplastic Agents, Phytogenic / adverse effects*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Brain Diseases / chemically induced*
  • Carboplatin / administration & dosage
  • Cerebral Ventricle Neoplasms / drug therapy*
  • Cerebral Ventricle Neoplasms / radiotherapy
  • Cerebral Ventricle Neoplasms / secondary*
  • Combined Modality Therapy
  • Consciousness Disorders / chemically induced
  • Cranial Irradiation
  • Cyclophosphamide / administration & dosage
  • Cytarabine / administration & dosage
  • Dacarbazine / administration & dosage
  • Dacarbazine / analogs & derivatives
  • Deoxycytidine / administration & dosage
  • Deoxycytidine / analogs & derivatives
  • Etoposide / administration & dosage
  • Female
  • Gemcitabine
  • Germinoma / drug therapy*
  • Germinoma / radiotherapy
  • Germinoma / secondary*
  • Germinoma / surgery
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Hypophysectomy
  • Neoplasm Recurrence, Local / drug therapy*
  • Neoplasm Recurrence, Local / radiotherapy
  • Organoplatinum Compounds / administration & dosage
  • Oxaliplatin
  • Paclitaxel / administration & dosage
  • Paclitaxel / adverse effects*
  • Pituitary Neoplasms / drug therapy*
  • Pituitary Neoplasms / radiotherapy
  • Pituitary Neoplasms / surgery
  • Temozolomide
  • Thiotepa / administration & dosage
  • Topotecan / administration & dosage

Substances

  • Antineoplastic Agents, Phytogenic
  • Organoplatinum Compounds
  • Cytarabine
  • Oxaliplatin
  • Deoxycytidine
  • Etoposide
  • Dacarbazine
  • Topotecan
  • Cyclophosphamide
  • Thiotepa
  • Carboplatin
  • Paclitaxel
  • Temozolomide
  • Gemcitabine