Abstract
Oxidative stress is an important susceptibility factor for dilated cardiomyopathy. We have investigated the effects of bisoprolol, a beta1-selective adrenoceptor blocker, on oxidative stress and the development of cardiac dysfunction in a model of dilated cardiomyopathy. Male TO-2 and control hamsters at 8 weeks of age were treated with bisoprolol (5 mg/kg per day) or vehicle for 4 weeks. Treatment with bisoprolol prevented the progression of cardiac dysfunction in TO-2 hamsters. This drug did not affect the increase in NADPH oxidase activity but prevented the reduction in activity and expression of mitochondrial manganese-dependent superoxide dismutase as well as the increases in the concentrations of interleukin-1beta and tumor necrosis factor-alpha in the left ventricle of TO-2 hamsters. Attenuation of the development of cardiac dysfunction by bisoprolol may thus result in part from normalization of the associated increases in the levels of oxidative stress and pro-inflammatory cytokines in the left ventricle.
MeSH terms
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Aldehydes / metabolism
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Animals
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Antioxidants / metabolism
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Bisoprolol / pharmacology*
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Blood Pressure / drug effects
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Body Weight / drug effects
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Cardiomyopathy, Dilated / chemically induced*
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Cardiomyopathy, Dilated / metabolism
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Cardiomyopathy, Dilated / pathology
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Cardiomyopathy, Dilated / physiopathology*
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Cricetinae
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Disease Models, Animal*
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Echocardiography
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Fibrosis / metabolism
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Fibrosis / pathology
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Glutathione / analogs & derivatives
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Glutathione / metabolism
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Heart Failure / chemically induced*
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Heart Failure / metabolism
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Heart Failure / pathology
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Heart Failure / physiopathology*
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Heart Rate / drug effects
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Interleukin-1 / metabolism
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Isoenzymes / metabolism
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Male
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NADPH Oxidases / metabolism
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Organ Size / drug effects
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Oxidative Stress / drug effects*
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Superoxide Dismutase / metabolism
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Tumor Necrosis Factor-alpha / metabolism
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Tyrosine / analogs & derivatives
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Tyrosine / metabolism
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Ventricular Function, Left
Substances
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Aldehydes
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Antioxidants
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Interleukin-1
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Isoenzymes
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Tumor Necrosis Factor-alpha
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3-nitrotyrosine
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Tyrosine
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Superoxide Dismutase
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NADPH Oxidases
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Glutathione
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4-hydroxy-2-nonenal
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Bisoprolol