Abstract
Six new cytotoxic bis-3-alkylpyridine alkaloids with an azoxy moiety, pyrinadines B-G (1-6), have been isolated from an Okinawan marine sponge Cribrochalina sp., and the structures were elucidated by spectroscopic data and chemical means.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry*
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Alkaloids / pharmacology
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Animals
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology
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Azo Compounds / chemistry*
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Humans
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KB Cells / drug effects
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Leukemia L1210 / drug therapy
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Mice
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Molecular Structure
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Porifera / chemistry*
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Pyridines / chemistry*
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Pyridines / pharmacology
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Tumor Cells, Cultured
Substances
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Alkaloids
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Antineoplastic Agents
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Azo Compounds
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Pyridines
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pyridine