Abstract
Several investigators have demonstrated the ability of CD8+ T cells from HIV-1 infected humans and SIV infected rhesus macaques to inhibit viral replication in vitro. In this report we show that CD8+ cells from naturally SIV infected sooty mangabeys also have the ability to inhibit viral replication in vitro. In addition, initial experiments which seek to elucidate the mechanism and antigen specificity of CD8-mediated suppression are described.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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B-Lymphocytes / immunology
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B-Lymphocytes / microbiology
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CD4 Antigens / genetics
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Cell Line, Transformed
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Cercopithecidae
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HIV-2 / immunology
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HIV-2 / physiology
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Herpesvirus 4, Human
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Humans
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RNA-Directed DNA Polymerase / metabolism
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Simian Acquired Immunodeficiency Syndrome / immunology*
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Simian Immunodeficiency Virus / enzymology
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Simian Immunodeficiency Virus / immunology*
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Simian Immunodeficiency Virus / physiology
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T-Lymphocytes, Regulatory / immunology*
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Virus Replication
Substances
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CD4 Antigens
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RNA-Directed DNA Polymerase