Discovering innate immunity genes using differential display: a story of RNA helicases

J Cell Physiol. 2006 Dec;209(3):636-44. doi: 10.1002/jcp.20797.

Abstract

In this review we discuss the current literature for RNA helicases in response to RNA virus infection. We show the use of Differential Display Reverse Transcription PCR methodology (DD) to analyze virus-host interactions and we present current findings in dengue virus-induced gene expression of RNA helicases.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line
  • DEAD Box Protein 58
  • DEAD-box RNA Helicases / genetics
  • DEAD-box RNA Helicases / metabolism*
  • Dengue / immunology
  • Dengue Virus / genetics
  • Dengue Virus / immunology
  • Gene Expression Profiling*
  • Gene Expression Regulation
  • Humans
  • Immunity, Innate / genetics*
  • Immunity, Innate / physiology
  • Interferon-Induced Helicase, IFIH1
  • Interferons / metabolism
  • Receptors, Immunologic

Substances

  • Receptors, Immunologic
  • Interferons
  • RIGI protein, human
  • IFIH1 protein, human
  • DEAD Box Protein 58
  • DEAD-box RNA Helicases
  • Interferon-Induced Helicase, IFIH1