Lessons learned from Art Pardee in cell cycle, science, and life

J Cell Physiol. 2006 Dec;209(3):663-9. doi: 10.1002/jcp.20800.

Abstract

This essay is written to honor Dr Art Pardee's 85th birthday (July 13, 2006). In this essay, I have summarized the lessons I learned from Art and the cell-cycle research I performed in Art's laboratory during my postdoctoral training period. I have also summarized some research from my own laboratory that has been inspired by the lessons I learned from Art, including the interactions between cell cycle and cell death regulators and discovery of novel polyphenol- and copper-based proteasome inhibitors. Finally, I have discussed the potential use of these proteasome inhibitors in cancer prevention and treatment.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Anticarcinogenic Agents / chemistry
  • Anticarcinogenic Agents / therapeutic use
  • Catechin / analogs & derivatives
  • Catechin / chemistry
  • Catechin / therapeutic use
  • Cell Cycle / physiology*
  • Cell Death / physiology
  • Copper / chemistry
  • Copper / therapeutic use
  • Cyclins / metabolism
  • Flavonoids / chemistry
  • Flavonoids / therapeutic use
  • Gene Expression Regulation
  • Humans
  • Molecular Structure
  • Multiprotein Complexes
  • Neoplasms* / metabolism
  • Neoplasms* / prevention & control
  • Neoplasms* / therapy
  • Phenols / chemistry
  • Phenols / therapeutic use
  • Polyphenols
  • Proteasome Endopeptidase Complex / metabolism
  • Proteasome Inhibitors
  • Research Personnel
  • Retinoblastoma Protein / metabolism

Substances

  • Anticarcinogenic Agents
  • Cyclins
  • Flavonoids
  • Multiprotein Complexes
  • Phenols
  • Polyphenols
  • Proteasome Inhibitors
  • Retinoblastoma Protein
  • Copper
  • Catechin
  • epigallocatechin gallate
  • Proteasome Endopeptidase Complex