Abstract
Imipenem-resistant Serratia marcescens isolates were cultured from a lung transplant patient given multiple antibiotics over several months. The strains expressed SME-3, a beta-lactamase of the rare SME carbapenem-hydrolyzing family. SME-3 differed from SME-1 by a single amino acid substitution of tyrosine for histidine at position 105, but the two beta-lactamases displayed similar hydrolytic profiles.
MeSH terms
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Anti-Bacterial Agents / metabolism
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Anti-Bacterial Agents / pharmacology*
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Carbapenems / metabolism*
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Carbapenems / pharmacology
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Humans
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Imipenem / metabolism
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Imipenem / pharmacology
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Kinetics
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Microbial Sensitivity Tests
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Middle Aged
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Serratia Infections / microbiology
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Serratia marcescens / drug effects*
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Serratia marcescens / enzymology*
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beta-Lactam Resistance*
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beta-Lactamases / classification
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beta-Lactamases / genetics
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beta-Lactamases / metabolism*
Substances
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Anti-Bacterial Agents
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Carbapenems
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Imipenem
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beta-Lactamases