Abstract
Children 17-20 months of age (N = 344) received a diphtheria-tetanus toxoids-acellular pertussis (DTPa)-inactivated poliovirus vaccine (IPV)/Haemophilus influenzae (Hib) booster after a 3-dose primary vaccination course with DTPa-hepatitis B vaccine-IPV/Hib plus conjugate meningococcal C vaccine-CRM. Seroprotection rates were >80% (diphtheria, tetanus, hepatitis B, polio and polyribosylribitol phosphate) before and > or =96.6% (diphtheria, tetanus, polio and polyribosylribitol phosphate) after booster vaccination. The booster was well-tolerated (fever >39.5 degrees C after <2% of doses; large swelling reactions after 6.3% of doses).
MeSH terms
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Adjuvants, Immunologic
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Antibodies, Bacterial / blood
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Antibodies, Viral / blood
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Bacterial Proteins / administration & dosage
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Bacterial Proteins / immunology*
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Diphtheria-Tetanus-Pertussis Vaccine
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Female
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Hepatitis B Vaccines / administration & dosage
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Hepatitis B Vaccines / immunology*
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Humans
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Immunization, Secondary
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Infant
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Male
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Meningococcal Vaccines / administration & dosage
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Meningococcal Vaccines / immunology*
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Poliovirus Vaccine, Inactivated
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Vaccination
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Vaccines, Combined / administration & dosage
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Vaccines, Combined / immunology*
Substances
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Adjuvants, Immunologic
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Antibodies, Bacterial
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Antibodies, Viral
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Bacterial Proteins
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DT5aP-Hib-IPV vaccine
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Diphtheria-Tetanus-Pertussis Vaccine
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Hepatitis B Vaccines
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Meningococcal Vaccines
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Poliovirus Vaccine, Inactivated
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Vaccines, Combined
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serogroup C meningococcal conjugate vaccine
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CRM197 (non-toxic variant of diphtheria toxin)