Are dose-finding studies still necessary when targeted therapy is associated with chemotherapy?

J Clin Oncol. 2006 Oct 1;24(28):4668-9; author reply 4669. doi: 10.1200/JCO.2006.08.3576.
No abstract available

Publication types

  • Comment
  • Letter

MeSH terms

  • Antibiotics, Antineoplastic / pharmacology
  • Antineoplastic Agents / adverse effects
  • Antineoplastic Agents / pharmacology*
  • Capecitabine
  • Clinical Trials as Topic / methods*
  • Cohort Studies
  • Data Interpretation, Statistical
  • Deoxycytidine / analogs & derivatives
  • Deoxycytidine / pharmacology
  • Erlotinib Hydrochloride
  • Fluorouracil / analogs & derivatives
  • Gastrointestinal Tract / drug effects
  • Humans
  • Middle Aged
  • Neoplasms / drug therapy*
  • Protein Kinase Inhibitors / pharmacology
  • Quinazolines / pharmacology
  • Research Design*

Substances

  • Antibiotics, Antineoplastic
  • Antineoplastic Agents
  • Protein Kinase Inhibitors
  • Quinazolines
  • Deoxycytidine
  • Capecitabine
  • Erlotinib Hydrochloride
  • Fluorouracil